MediciNova Receives Notice of Allowance for New Patent Covering the Combination of MN-166 (ibudilast) and Riluzole for the Treatment of Amyotrophic Lateral Sclerosis (ALS) in Japan


LA JOLLA, Calif., Jan. 18, 2021 (GLOBE NEWSWIRE) — MediciNova, Inc., a biopharmaceutical firm traded on the NASDAQ World Market (NASDAQ:MNOV) and the JASDAQ Market of the Tokyo Inventory Alternate (Code Quantity: 4875), in the present day introduced that it has obtained a Discover of Allowance from the Japan Patent Workplace for a pending patent software which covers the mixture of MN-166 (ibudilast) and riluzole for the therapy of amyotrophic lateral sclerosis (ALS).

As soon as issued, the patent maturing from this allowed patent software is anticipated to run out no sooner than November 2035. The allowed claims cowl the mixture of MN-166 (ibudilast) and riluzole for assuaging the damaging results of ALS, treating a affected person identified with ALS, and slowing development of illness in a affected person identified with ALS.   The allowed claims cowl a variety of doses and dosing regimens for each MN-166 (ibudilast) and riluzole.

Yuichi Iwaki, MD, PhD, President and Chief Govt Officer of MediciNova, Inc., commented, “We’re very happy to obtain discover that this new patent will probably be granted. We imagine it may considerably enhance the potential worth of MN-166 as sufferers are utilizing the mixture of MN-166 and riluzole in our ongoing Part 3 medical trial in ALS.  Beforehand, the same patent was granted within the U.S., the U.S. FDA granted each orphan-drug designation and fast-track designation to MN-166 for the therapy of ALS, and the European Fee granted Orphan Medicinal Product Designation to MN-166 for the therapy of ALS.”

About ALS

Amyotrophic lateral sclerosis (ALS), often known as Lou Gehrig’s illness, is a progressive neurodegenerative illness that impacts nerve cells within the mind and the spinal twine. The nerves lose the flexibility to set off particular muscle mass, which causes the muscle mass to turn into weak. Consequently, ALS impacts voluntary motion and sufferers within the later levels of the illness might turn into fully paralyzed. Life expectancy of an ALS affected person is normally 2-5 years. In line with the ALS Affiliation, there are roughly 20,000 ALS sufferers within the U.S. and roughly 5,000 individuals within the U.S. are identified with ALS every year.

About MN-166 (ibudilast)

MN-166 (ibudilast) is a first-in-class, orally bioavailable, small molecule macrophage migration inhibitory issue (MIF) inhibitor and phosphodiesterase (PDE) -4 and -10 inhibitor that suppresses pro-inflammatory cytokines and promotes neurotrophic components. Our earlier human research demonstrated important reductions of serum MIF degree after therapy with MN-166 (ibudilast). It additionally attenuates activated glial cells, which play a serious position in sure neurological situations. MN-166 (ibudilast)’s anti-neuroinflammatory and neuroprotective actions have been demonstrated in preclinical and medical research, which offer the rationale for therapy of amyotrophic lateral sclerosis (ALS), progressive a number of sclerosis (MS) and different neurological ailments comparable to glioblastoma (GBM), and substance abuse/habit. MediciNova is growing MN-166 for ALS, progressive MS and different neurological situations comparable to degenerative cervical myelopathy (DCM), glioblastoma, substance abuse/habit, and chemotherapy-induced peripheral neuropathy, in addition to prevention of acute respiratory misery syndrome (ARDS) brought on by COVID-19. MediciNova has a portfolio of patents which covers the usage of MN-166 (ibudilast) to deal with numerous ailments together with ALS, progressive MS, and drug habit.

About MediciNova

MediciNova, Inc. is a publicly-traded biopharmaceutical firm based upon growing novel, small-molecule therapeutics for the therapy of ailments with unmet medical wants with a main industrial give attention to the U.S. market. MediciNova’s present technique is to give attention to BC-PIV SARS-COV-2 vaccine for COVID-19, MN-166 (ibudilast) for neurological issues comparable to progressive a number of sclerosis (MS), amyotrophic lateral sclerosis (ALS), degenerative cervical myelopathy (DCM), substance dependence (e.g., alcohol use dysfunction, methamphetamine dependence, opioid dependence) and glioblastoma (GBM), in addition to prevention of acute respiratory misery syndrome (ARDS) brought on by COVID-19, and MN-001 (tipelukast) for fibrotic ailments comparable to nonalcoholic steatohepatitis (NASH) and idiopathic pulmonary fibrosis (IPF). MediciNova’s pipeline additionally contains MN-221 (bedoradrine) and MN-029 (denibulin). For extra data on MediciNova, Inc., please go to www.medicinova.com.

Statements on this press launch that aren’t historic in nature represent forward-looking statements inside the that means of the secure harbor provisions of the Non-public Securities Litigation Reform Act of 1995. These forward-looking statements embrace, with out limitation, statements relating to the long run growth and efficacy of BC-PIV SARS-COV-2 vaccine, MN-166, MN-001, MN-221, and MN-029. These forward-looking statements could also be preceded by, adopted by or in any other case embrace the phrases “believes,” “expects,” “anticipates,” “intends,” “estimates,” “initiatives,” “can,” “may,” “might,” “will,” “would,” “contemplating,” “planning” or comparable expressions. These forward-looking statements contain quite a lot of dangers and uncertainties which will trigger precise outcomes or occasions to vary materially from these expressed or implied by such forward-looking statements. Elements which will trigger precise outcomes or occasions to vary materially from these expressed or implied by these forward-looking statements embrace, however aren’t restricted to, dangers of acquiring future associate or grant funding for growth of BC-PIV SARS-COV-2 vaccine, MN-166, MN-001, MN-221, and MN-029 and dangers of elevating adequate capital when wanted to fund MediciNova’s operations and contribution to medical growth, dangers and uncertainties inherent in medical trials, together with the potential price, anticipated timing and dangers related to medical trials designed to fulfill FDA steering and the viability of additional growth contemplating these components, product growth and commercialization dangers, the uncertainty of whether or not the outcomes of medical trials will probably be predictive of leads to later levels of product growth, the danger of delays or failure to acquire or keep regulatory approval, dangers related to the reliance on third events to sponsor and fund medical trials, dangers relating to mental property rights in product candidates and the flexibility to defend and implement such mental property rights, the danger of failure of the third events upon whom MediciNova depends to conduct its medical trials and manufacture its product candidates to carry out as anticipated, the danger of elevated price and delays resulting from delays within the graduation, enrollment, completion or evaluation of medical trials or important points relating to the adequacy of medical trial designs or the execution of medical trials, and the timing of anticipated filings with the regulatory authorities, MediciNova’s collaborations with third events, the supply of funds to finish product growth plans and MediciNova’s capacity to acquire third social gathering funding for applications and lift adequate capital when wanted, and the opposite dangers and uncertainties described in MediciNova’s filings with the Securities and Alternate Fee, together with its annual report on Kind 10-Ok for the yr ended December 31, 2019 and its subsequent periodic experiences on Kind 10-Q and present experiences on Kind 8-Ok. Undue reliance shouldn’t be positioned on these forward-looking statements, which communicate solely as of the date hereof. MediciNova disclaims any intent or obligation to revise or replace these forward-looking statements.

INVESTOR CONTACT:

Geoff O’Brien

Vice President

MediciNova, Inc.
info@medicinova.com


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